Premium
Cellular immune response levels in gestational trophoblastic tumor patients after hydatidiform mole
Author(s) -
Sutoto M.T.
Publication year - 1999
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/s0020-7292(99)00021-1
Subject(s) - medicine , immune system , logistic regression , gestation , gestational age , gastroenterology , natural killer cell , prospective cohort study , pregnancy , immunology , andrology , cytotoxic t cell , biology , biochemistry , in vitro , genetics
Objective : This study looked for an association of natural (innate) cellular immune responses with the development of gestational trophoblastic tumors (GTT) after hydatidiform moles (HM). Method : An observational prospective cohort study (73 patients) was carried out to measure the serum level of Natural Killer (NK) cells, Monocytes (Mo) and a Bio‐Merieux skin test was performed on the day of HM evacuation and 4 weeks afterwards. The diagnosis of GTT were after Soper and Hammond (1998) and followed up for at least 6 months after evacuation. Patients' characteristics and cellular immune responses among patients who developed GTT were analysed by multiple logistic regression (SPSS version 5). Results : The results showed that a low NK cell percentage was associated ( P =0.020) with the development of GTT, also a low Mo ( P =0.034) on day 0. While on day 28 a low NK cell percentage ( P =0.008) and Mo cell count ( P =0.043) were associated with the development of GTT. The cut‐off point between the sensitivity (60%) and specificity of NK cell percentage on day 0 was 16, and also showed a negative predictive value of 83%. Meanwhile on day 28, the cut‐off point between the sensitivity and specificity (80%) was 17, and showed a negative predictive value of NK cell percentage (85%). Conclusion : These figures indicated that HM‐lowered NK cell serum percentages were associated with the development of GTT.