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Estrogen therapy for depression in postmenopausal women
Author(s) -
CarranzaLira S,
ValentinoFigueroa M.L
Publication year - 1999
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/s0020-7292(99)00017-x
Subject(s) - medicine , estrogen , estrogen therapy , depression (economics) , estrogen replacement therapy , postmenopausal women , menopause , gynecology , obstetrics , economics , macroeconomics
Objective : To look at the modification in depressive mood in postmenopausal depressed women after estrogen replacement therapy (ERT). Method : Twelve depressed patients divided into two groups of six women each were studied. One group received conjugated equine estrogens (CEE) 0.625 mg/day; the other did not receive any treatment (control group). Mood was assessed in all the subjects at baseline and at 6 months with Hamilton Rating Scale score and considered as depression when it was >15. Differences between groups were determined by Mann–Whitney U ‐test, and in each group between baseline and 6‐month values with Wilcoxon test. Results : The ERT group had a statistically significant decrease in depressive mood (21 vs. 13 points, P <0.03), while in the control group no significant change was found. Final Hamilton scale scores were significantly lower ( P <0.05) in those under ERT, when compared with those in the control group. Conclusion : Depressive mood decreased after 6 months with CEE, so the prescription of ERT can be useful in postmenopausal women with depressive mood.