Premium
Biochemical markers of bone turnover during hormone replacement therapy
Author(s) -
Masahashi T,
Negoro Y,
Kuroki T,
Asai M,
Noguchi M,
Nakanishi M
Publication year - 1999
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/s0020-7292(98)00249-5
Subject(s) - deoxypyridinoline , pyridinoline , medicine , bone remodeling , hormone replacement therapy (female to male) , bone mineral , osteocalcin , endocrinology , estrogen , urology , osteoporosis , alkaline phosphatase , biology , biochemistry , testosterone (patch) , enzyme
Objective : To assess the clinical usefulness of bone turnover markers, including serum osteocalcin (OC), urinary pyridinoline (Pyr) and deoxypyridinoline (D‐Pyr), in monitoring and predicting bone response to hormone replacement therapy (HRT). Method : The relationships between baseline levels or changes in markers and change in lumbar bone mineral density were examined in 21 surgically‐induced postmenopausal women. Results : Levels of OC, Pyr and D‐Pyr in the estrogen effective group (responders) significantly decreased during HRT and baseline levels of Pyr and D‐Pyr in responders were significantly higher than those in premenopausal women. Conclusion : Bone turnover markers were useful in monitoring the bone effect of HRT and baseline levels of markers reflect subsequent bone response to HRT.