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Laminaria and sulprostone in second trimester pregnancy termination for fetal abnormalities
Author(s) -
Chung Y.P,
Hwa H.L,
Ko T.M
Publication year - 1999
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/s0020-7292(98)00219-7
Subject(s) - medicine , laminaria , abortion , vomiting , pregnancy , nausea , obstetrics , fetus , gestation , anesthesia , gynecology , ecology , genetics , algae , biology
The efficacy and safety of intracervical placement of laminaria and intravenous prostaglandin E 2 (sulprostone) infusion for termination of second‐trimester pregnancies with abnormal fetuses was investigated. One hundred and six pregnant women at 13–29 weeks' gestation with fetal anomalies underwent laminaria tent insertion into the cervical canal on admission. The next morning, Sulprostone infusion was started at a rate of 16 μg/h and increased by 16 μg/h every 30 min to induce uterine contractions. Induction‐to‐abortion time (IAT), success and complete abortion rates, and sulprostone‐related side effects were registered. The overall success and complete abortion rates within 24 h were 91.5 and 80.2%, respectively. The mean IAT was 12.1±7.6 h. The incidence of nausea and/or vomiting was 17.9%, with 1.7 episodes per case. Diarrhea and fever (9.5%) were not common. Laminaria tent insertion plus sulprostone infusion was an effective and safe regimen for second‐trimester termination of pregnancy with live fetuses.