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Vascular cell adhesion molecule‐1 (VCAM‐1) and leukocyte activation in pre‐eclampsia and eclampsia
Author(s) -
Budak E,
Madazli R,
Aksu M.F,
Benian A,
Gezer A,
Palit N,
Yildizfer F
Publication year - 1998
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/s0020-7292(98)00138-6
Subject(s) - eclampsia , vcam 1 , medicine , preeclampsia , pregnancy , cell adhesion molecule , immunology , icam 1 , biology , genetics
Objective: To evaluate the levels of VCAM‐1 in pre‐eclampsia/eclampsia as a possible marker of leukocyte activation and endothelial damage. Methods: We performed a case‐control study on 25 healthy pregnant women and 35 patients diagnosed as pre‐eclampsia or eclampsia which were randomly selected. Peripheral venous blood samples were obtained and serum levels of VCAM‐1 were measured by enzyme‐linked immunoassay (ELISA). Results: In pre‐eclampsia/eclampsia, VCAM‐1 levels were higher than in normal pregnancy. Serum concentrations of VCAM‐1 were significantly higher in severe pre‐eclampsia and eclampsia compared to mild pre‐eclampsia or healthy controls. ROC analysis detected that VCAM‐1 ≥450 ng/ml had a sensitivity of 0.79 and a specificity of 0.90 in detecting severe pre‐eclampsia and eclampsia. Conclusion: This is the first study to correlate VCAM‐1 levels with severity of disease in pre‐eclampsia. Our findings indicate that increasing levels of soluble VCAM‐1 are present in the circulation of patients with severe pre‐eclampsia/eclampsia compared to mild pre‐eclampsia or healthy pregnant women. Elevated VCAM‐1 levels may represent a possible mechanism by which endothelial cells attract leukocytes and cause endothelial cell damage.