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Polymorphism of the β 3 ‐adrenergic‐receptor gene associated with maternal body weight gain and fetal body weight
Author(s) -
Arakawa M,
Kurabayashi T,
Tomita M,
Yahata T,
Takakuwa K,
Tanaka K
Publication year - 1998
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/s0020-7292(98)00112-x
Subject(s) - heterozygote advantage , medicine , pregnancy , fetus , genotype , allele , endocrinology , polymorphism (computer science) , body mass index , compound heterozygosity , weight gain , body weight , gene , genetics , biology
Objective: To investigate whether the polymorphism of the β 3 ‐adrenergic‐receptor (β 3 ‐AR) gene was associated with the maternal and fetal conditions during pregnancy. Method: The association between the genotypes of β 3 ‐AR and clinical phenotypes during pregnancy was analyzed in 92 women (a total of 126 pregnancies). Result: The overall frequency of the Trp64Arg β 3 ‐AR allele in 92 pregnant Japanese women was 20.7%. In 125 pregnancies, excluding one homozygote (51 heterozygote group and 74 wild‐type group), a significant difference in the maternal body weight gain during pregnancy was observed between the heterozygote group and wild‐type group. The heterozygote group had significantly higher neonatal body weights, neonatal body weight index values and placental weights compared with the wild‐type group. Conclusion: The Trp64Arg heterozygous mutation in the β 3 ‐AR gene is associated with not only the increase in the body weight of pregnant Japanese women but also the increase in the weights of their neonate and placentas.