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Maternal sickle cell anemia and neonatal isoimmunization
Author(s) -
Narchi H,
EkumaNkama E
Publication year - 1998
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/s0020-7292(98)00067-8
Subject(s) - medicine , abo blood group system , reticulocytosis , jaundice , anemia , offspring , obstetrics , abo incompatibility , rh isoimmunization , blood transfusion , sickle cell anemia , exchange transfusion , pediatrics , pregnancy , immunology , disease , fetus , genetics , biology
Objective : To study the risk of alloimmunization in pregnant women with sickle cell disease (SCD) and of isoimmunization in their offspring. Method : Thirty mothers with SCD were studied and their 35 neonates (group 1) were compared with 538 infants of mothers without hemoglobinopathies (group 2). Result : Six mothers with SCD developed alloantibodies. There was no correlation with maternal age ( P =0.6), parity ( P =0.18) or blood transfusions ( P =0.4). The risk of alloimmunization by transfusion was 20%. Six neonates were isoimmunized, a higher incidence than in group 2 ( P =0.02; relative risk 3.07). Five had ABO incompatibility and only one had anti‐c isoimmunization. All had reticulocytosis, jaundice and required phototherapy, one developed anemia but none required blood transfusion. Conclusion : Although alloimmunization was common in mothers with SCD and isoimmunization in their offspring, it was rarely due to non‐ABO alloantibody. There was no significant neonatal morbidity.