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Systemic antibiotic prophylaxis in elective cesarean delivery
Author(s) -
Rizk D.E.E,
Nsanze H,
Mabrouk M.H,
Mustafa N,
Thomas L,
Kumar M
Publication year - 1998
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/s0020-7292(98)00062-9
Subject(s) - medicine , endometritis , cefuroxime , antibiotics , antibiotic prophylaxis , cesarean delivery , randomized controlled trial , pregnancy , surgery , obstetrics , anesthesia , genetics , microbiology and biotechnology , biology
Objective: To test the value of using prophylactic antibiotics at elective cesarean delivery. Method: One‐hundred and twenty women delivered by elective cesarean in the absence of labor and before the rupture of membranes were randomized to receive either 1.5 g of cefuroxime intravenously at cord clamping ( n =59) or no prophylaxis (control group, n =61). Results: Twelve women developed febrile morbidity (six study, six control, P =0.09). Of these, five had endometritis (two study, three control, P =0.09) and two had wound infection (one study, one control, P =0.09). Ten more women had microbiological evidence of endometritis and wound infection (six study, four control, P =0.08). There was no significant difference in the hospital stay (6.5 days study, 6.8 days control, P =0.06). Staphylococcus aureus was the commonest pathogen accounting for 14 infection episodes. Amniotic fluid culture could not predict the development of infection. Conclusion: Administration of prophylactic antibiotics at elective cesarean deliveries was not associated with decreased postoperative morbidity.