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A prospective, randomized trial of nifedipine vs. ritodrine in threatened preterm labor
Author(s) -
Garcı́aVelasco J.A,
González González A
Publication year - 1998
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/s0020-7292(98)00053-8
Subject(s) - ritodrine , nifedipine , medicine , tocolytic agent , tocolytic , randomized controlled trial , umbilical artery , obstetrics , gestation , randomization , fetus , anesthesia , prospective cohort study , preterm labor , pregnancy , genetics , biology , calcium
Objectives: To compare the tocolytic efficacy and maternal tolerance of nifedipine with ritodrine in the management of threatened preterm labor. Methods: Prospective randomized study of 52 singleton pregnancies with preterm labor between 26 and 34 week's gestation. The capacity to delay delivery 48 h, 7 days, until week 36 or until fetal weight reached 2500 g were the outcome variables assessed. Doppler ultrasound studies were performed on the fetal umbilical artery as control. Results: No significant differences were found in the delay of delivery, but significantly fewer maternal side‐effects were found in the nifedipine group. Doppler ultrasound results were similar in both groups. Conclusions: Nifedipine is a valid and well‐tolerated alternative among the tocolytic drugs, and apparently does not significantly alter fetal vascular blood flow.