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Human papillomavirus (HPV) DNA assay as an adjunct to liquid‐based Pap test in the diagnostic triage of women with an abnormal Pap smear
Author(s) -
Vassilakos P.,
Marval F.,
Muñoz M.,
Broquet G.,
Campana A.
Publication year - 1998
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/s0020-7292(98)00012-5
Subject(s) - medicine , predictive value , triage , human papillomavirus , pap test , cytology , predictive value of tests , cervical cancer , positive predicative value , colposcopy , cervical intraepithelial neoplasia , adjunct , dna testing , gynecology , obstetrics , cervical cancer screening , cancer , pathology , emergency medicine , biology , genetics , linguistics , philosophy
Objective: The diagnostic performance and clinical value of the combined use of liquid‐based Pap test and human papillomavirus testing were determined in 336 patients with a previous abnormal smear. Method: Subsequent histologic evaluation was used as definitive diagnosis. Result: The combined use of liquid‐based Pap test and HPV DNA testing showed higher rates in sensitivity (99.0%), specificity (59.3%), positive predictive value (89.9%) and negative predictive value (94.5%) than either cytology alone (sensitivity 98.8%, specificity 45.7%, positive predictive value 84.7%, negative predictive value 92.6%) or HPV DNA testing alone (sensitivity 84.9%, specificity 67.4%, positive predictive value 88.8%, negative predictive value 59.5%). Conclusion: The study demonstrated that the diagnostic accuracy for cervical cancer and its precursors was improved by using the liquid‐based Pap test as a primary diagnostic procedure and HPV assay as an adjunctive test. This information may assist the clinicians in triaging patients with equivocal cytologic cervical atypias.