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Erythropoietin in amniotic fluid as a marker of chronic fetal hypoxia
Author(s) -
Buescher U,
Hertwig K,
Wolf C,
Dudenhausen J.W
Publication year - 1998
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/s0020-7292(98)00011-3
Subject(s) - medicine , erythropoietin , amniotic fluid , amniocentesis , fetal hypoxia , hypoxia (environmental) , fetus , andrology , obstetrics , physiology , pregnancy , prenatal diagnosis , endocrinology , oxygen , chemistry , organic chemistry , biology , genetics
Objective: To determinate the erythropoietin concentration in amniotic fluid in normal pregnancies and pregnancies with suspected hypoxia. Method: The erythropoietin concentration of 164 samples of amniotic fluid was determined by ELISA. The samples were taken by amniotomy during birth, as well as amniocentesis conducted during prenatal care. Results: A distribution of 1.07–7.29 U/l (10th–90th percentile) within the normal group ( n =106) was determined. Significantly elevated erythropoietin levels in amniotic fluid were determined in maternal hypertension ( P =0.039) and low birth‐weight children ( P =0.0032). A correlation with the child's sex could be excluded. Conclusion: Elevated erythropoietin levels in amniotic fluid indicated chronic fetal hypoxia.