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Interleukin‐8 level in maternal serum as a marker for screening of histological chorioamnionitis at term
Author(s) -
Shimoya K.,
Matsuzaki N.,
Taniguchi T.,
Okada T.,
Saji F.,
Murata Y.
Publication year - 1997
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/s0020-7292(97)02891-9
Subject(s) - chorioamnionitis , medicine , interleukin , cord blood , pregnancy , immunology , gestation , obstetrics , cytokine , biology , genetics
Objective: To establish a clinical method for immediate diagnosis of histological chorioamnionitis, by maternal blood sampling at term. Method: The sera of 22 mothers with chorioamnionitis and 81 mothers without chorioamnionitis at term delivery were collected. The serum levels of cytokines including interleukin‐1α (IL‐1α), interleukin‐1β (IL‐1β), tumor necrosis factor‐α (TNF‐α), interleukin‐6 (IL‐6) and interleukin‐8 (IL‐8) were titered and other conventional markers such as white blood cell and CRP were measured simultaneously. Chorioamnionitis was histopathologically confirmed after delivery. Result: The sera of mothers with histological chorioamnionitis showed a significant increase in IL‐8 titer, but not in those of other cytokines or conventional markers, compared with those without chorioamnionitis. A positive correlation was observed between maternal and cord serum IL‐8 levels. Maternal IL‐8 showed the highest predictive value for diagnosis of histological chorioamnionitis. Conclusion: Measurement of maternal IL‐8 is useful for rapid prenatal screening of histological chorioamnionitis at term.