Premium
Micronized flavonoid therapy in internal hemorrhoids of pregnancy
Author(s) -
Buckshee K.,
Takkar D.,
Aggarwal N.
Publication year - 1997
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/s0020-7292(97)02889-0
Subject(s) - diosmin , medicine , hemorrhoids , hesperidin , pregnancy , confidence interval , adverse effect , randomized controlled trial , surgery , obstetrics , alternative medicine , pathology , biology , genetics
Objective: To assess the safety, efficacy and acceptability of a micronized flavonoid formulation in the treatment of internal hemorrhoids of pregnancy. Method: In an open study on hospital outpatients, we studied therapy with micronized diosmin 90% and hesperidin 10% for a median of 8 weeks before delivery and 4 weeks after delivery, in 50 women with acute hemorrhoids. The outcome measures were symptoms and signs of hemorrhoids; adverse effects; and acceptability of treatment. Result: On intention to treat analysis, 66% (95% confidence interval, range 79.1–52.9) had relief from acute symptoms by the 4th day; 53.6% (95% confidence interval, range 70–37.1, P < 0.001) fewer patients had relapse in the antenatal period. Treatment was well accepted, and did not affect pregnancy, fetal development, birth weight, infant growth and feeding. Conclusion: In the short term, micronized diosmin 90% and hesperidin 10% is safe, acceptable, and effective in the treatment of hemorrhoids of pregnancy.