Premium
Effect of long‐term hormone replacement therapy on the bone in ovariectomized women with cancer
Author(s) -
Kurabayashi T,
Yahata T,
Honda A,
Tomita M,
Yasuda M,
Tanaka T
Publication year - 1998
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/s0020-7292(97)00272-5
Subject(s) - medicine , ovariectomized rat , medroxyprogesterone acetate , hormone replacement therapy (female to male) , bone mineral , estrogen , medroxyprogesterone , regimen , endocrinology , bone remodeling , bone density , urology , gynecology , osteoporosis , testosterone (patch)
Objective: To evaluate longitudinally the effectiveness of long‐term hormone replacement therapy (HRT) in preserving the bone mineral density (BMD) over a 5‐year period in ovariectomized patients treated for gynecologic malignancies. Methods: A total of 70 pre‐menopausal women ovariectomized for gynecologic malignancies at our hospital were divided non‐randomly into two groups: HRT (+) group ( n =59) and HRT (−) group ( n =11). HRT was administered in a sequential regimen of 0.625–1.25 mg conjugated estrogen for 24 days and 5–10 mg medroxyprogesterone acetate for 10 days. Results: The BMD of the lumbar vertebrae decreased significantly in the HRT (−) group (pre‐operative BMD was 91.8%, 91.0% and 91.3% at 1, 2 and 3 years post‐ovariectomy), but no decrease in the BMD was observed in the HRT (+) group (pre‐operative BMD was 98.4%, 99.0%, 99.4%, 98.8% and 98.7% at 1, 2, 3, 4 and 5 years post‐ovariectomy); the difference in BMD between the two groups was statistically significant ( P <0.01). Serum alkaline phosphatase levels were significantly lower in the HRT (+) group than in the HRT (−) group ( P <0.01). There were four recurrences of cancer in the HRT (+) group. Conclusion: HRT appeared to have beneficial effects on bone metabolism by maintaining BMD for 5 years in ovariectomized patients for gynecologic malignancies.