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A randomized controlled trial of low‐dose aspirin in women at risk from pre‐eclampsia
Author(s) -
Byaruhanga R.N,
Chipato T,
Rusakaniko S
Publication year - 1998
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/s0020-7292(97)00257-9
Subject(s) - medicine , eclampsia , aspirin , randomized controlled trial , low dose aspirin , obstetrics , pregnancy , genetics , biology
Objectives: To determine whether low‐dose aspirin reduces the incidence of pre‐eclampsia, reduces perinatal mortality and improves birth weights in pregnant women considered at high risk of developing pre‐eclampsia. Method: Two‐hundred fifty subjects were recruited from the antenatal clinics at Harare Central Hospital with either a previous history of pregnancy‐induced hypertension or pre‐existing chronic hypertension and were randomized to receive either 75 mg of aspirin (ASA) or placebo (PLA). Results: Two‐hundred thirty subjects (ASA, n =113; PLA, n =117) completed the trial. The odds of developing pre‐eclampsia for those on aspirin was 0.72 times those on placebo (95% CI, 0.34–1.52). The mean birth weight was 2774 g for those on aspirin and 2694 g for those on placebo ( P =0.80). No difference was noted in the perinatal deaths (OR=0.38; 95% CI, 0.10–1.20). Conclusion: Prophylactic use of aspirin was not associated with a significant effect on the major pregnancy outcomes assessed in this study.