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Timing of insults causing abnormal outcome in preterm infants 1989–1992
Author(s) -
Morikawa S.,
Itakura A.,
Hayakawa F.,
Mizutani S.,
Matsuzawa K.,
Kurauchi O.
Publication year - 1997
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/s0020-7292(97)00112-4
Subject(s) - medicine , pediatrics , insult , fetus , obstetrics , pregnancy , philosophy , linguistics , biology , genetics
Objective: The purpose of this study was to clarify the influence of timing of brain insults causing abnormal outcome in preterm infants. Methods: One hundred and thirty‐one preterm infants were examined. The timing of brain insult was estimated from EEG or clinical findings. Development was assessed until a corrected age of 48 months. Results: 39% and 4% of infants, respectively, born before and after the 28‐week time point subsequently died (P < 0.05). Abnormal development was observed in 16% of the first group and 13% of the second (N.S.). None of those born before 28 weeks showed intrauterine injuries while nine of the infants which were born after this time showed intrauterine injuries (P < 0.05). Fetal distress was noted in all infants suffering neonatal death born after 28 weeks. Conclusion: Intrauterine brain insult was concluded to be the cause of neonatal death or abnormal development in many infants born after 28 weeks.