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Lipids in serum of patients with malignant ovarian neoplasms
Author(s) -
Gadomska H.,
Janecki J.,
Marianowski L.,
Nowicka G.
Publication year - 1997
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/s0020-7292(97)00071-4
Subject(s) - ovarian cancer , multivariate analysis , cholesterol , medicine , blood lipids , analysis of variance , lipoprotein , endocrinology , cancer , high density lipoprotein , ovarian carcinoma , total cholesterol
Objective: In numerous papers, different associations of serum lipids and lipoproteins with neoplastic diseases were found. The aim of our work was to find out associations between levels of 11 serum lipids, lipoproteins and ovarian cancer. Methods: 25 healthy women and 25 patients with ovarian cancer underwent examinations. Uni‐ and multivariate analysis of variance and discrimination analysis were used to analyze our results. Results: The analysis demonstrates that ovarian carcinoma is associated with a significant reduction of total cholesterol and its esters in serum and in high density lipoprotein fractions compared to controls. Conclusion: It could be shown that using multivariate analysis of variance it is possible to find the optimal set of serum lipid parameters, containing serum esterified cholesterol, serum total cholesterol and high density lipoproteins esterified cholesterol, to differentiate healthy persons from patients affected by ovarian cancer.