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Pregnancy‐induced hypertension and hyaline membrane disease
Author(s) -
Carvalho M.A.,
Faúndes A.,
Santos L.C.
Publication year - 1997
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/s0020-7292(97)00066-0
Subject(s) - medicine , gestational age , gestational hypertension , obstetrics , hyaline , logistic regression , eclampsia , pregnancy , relative risk , incidence (geometry) , prospective cohort study , cohort study , gestation , retrospective cohort study , confidence interval , pathology , genetics , physics , optics , biology
Objectives: (1) To determine whether the incidence of hyaline membrane disease (HMD) is different among premature babies of pre‐eclamptic women and those of normotensive controls; (2) to determine the relative risk (RR) of HMD according to the severity of pre‐eclampsia and gestational age. Methods: A retrospective and prospective cohort of 271 pre‐eclamptic women and 271 normotensive controls, with gestational age between 28 and 34 weeks was studied, including only singleton pregnancies, live fetuses and well‐documented gestational age. Exclusion criteria were ruptured membranes > 24 h, other maternal diseases and previous use of corticosteroids. Statistical analysis included relative risk and multiple logistic regression model. Results: The RR of HMD for babies of pre‐eclamptic women was 0.96 (95% CI: 0.78–1.17), and remained unchanged after controlling for gestational age and multiple logistic regression analysis. Conclusion: Preterm babies of pre‐eclamptic mothers had the same probability of having HMD as newborns of normotensive mothers.