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Hyperinsulinemia increases the risk of gestational hypertension
Author(s) -
Hamasaki Tetsushi,
Yasuhi Ichiro,
Hirai Masanao,
Masuzaki Hideaki,
Ishimaru Tadayuki
Publication year - 1996
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/s0020-7292(96)02759-2
Subject(s) - hyperinsulinemia , medicine , body mass index , blood pressure , gestational hypertension , endocrinology , gestational age , glucose tolerance test , insulin , gestation , pregnancy , gestational diabetes , obstetrics , insulin resistance , biology , genetics
Objective: To determine whether hyperinsulinemia is related to gestational hypertension. Methods: We measured the arterial blood pressure and the level of immunoreactive insulin (IRI) during a 75 g oral glucose tolerance test in a total of 84 pregnant women. Hyperinsulinemia was defined as a fasting IRI level ≥ 9 IU/1, while gestational hypertension was defined as arterial blood pressure ≥ 140/90 mmHg. Results: The incidence of gestational hypertension was higher in the hyperinsulinemic group (n = 29) than in the control group (n = 55) (24.1% vs. 7.3%, respectively P < 0.05). After controlling for maternal age, parity, pre‐pregnancy body mass index and the gestational age at the time of oral glucose tolerance test (OGTT), using a multiple regression model, the relative risk of developing gestational hypertension for a fasting insulin level was 1.19 (95% C.I., 1.03–1.38). Conclusion: Pregnant women with hyperinsulinemia are at increased risk of developing gestational hypertension.