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W180 ANTICARDIOLIPIN ANTIBODY IN WOMEN WITH RECURRENT SPONTANEOUS MISCARRIAGE
Author(s) -
Mahdi N.K.
Publication year - 2012
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/s0020-7292(12)61905-5
Subject(s) - medicine , miscarriage , anticardiolipin antibodies , citation , recurrent miscarriage , gynecology , obstetrics and gynaecology , obstetrics , antibody , library science , pregnancy , immunology , genetics , computer science , biology
OBJECTIVETo determine the association between the presence of anticardiolipin antibody (ACA) and history of recurrent spontaneous miscarriage. Also, to evaluate the association between raised ACA and activated partial thromboplastin time (APTT).METHODSThis is a case-control study which was carried out in Basrah Hospital for Maternity and Children, Basrah, Iraq during January to September 2004 on 91 women with recurrent spontaneous miscarriage, matched with 109 women with no history of pregnancy wastage. Sera were collected from these 200 women and analyzed for ACA by enzyme linked immunosorbent assay (ELISA).RESULTSIn women with pregnancies that ended with a loss, 17.6% were positive of ACA, compared with none among the control group. Women with 4 or more miscarriages had almost higher percentages of ACA (26.3% and 22.2%) than women with only 3 miscarriages (13%) but with no statistical significance. Prolonged APTT was detected among 18.8% of patients having positive ACA while only 1.6% of patients who were negative for this antibody.CONCLUSIONA significant association was observed between recurrent spontaneous miscarriage and the presence of ACA. Also, there was a significant relationship between positive ACA and prolonged APTT.