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8‐year follow‐up in a randomized trial of one vs two transcervival insertions of quinacrine pellets for sterilization in Indonesia
Author(s) -
Agoestina T.
Publication year - 2003
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/s0020-7292(03)90104-4
Subject(s) - medicine , sterilization (economics) , randomized controlled trial , family planning , pregnancy , female sterilization , obstetrics , surgery , gynecology , population , research methodology , environmental health , genetics , biology , monetary economics , economics , foreign exchange market , foreign exchange
Objective: To evaluate the efficacy of one vs two insertions of quinacrine and the long‐term safety of quinacrine sterilization (QS) 8 years after the procedure in Indonesia. Methods: Between March 1993 and September 1995, a randomized trial was conducted in 6 academic centers in Indonesia. In February 2003, a follow‐up was undertaken in Bandung, one of these centers. This survey required a home visit of each woman. A questionaire was designed to elicit information regarding current general health status, method failure, pregnancy outcomes and other contraceptive methods now used by women who experienced failures. Among the 70 patients receiving a single insertion of quinacrine pellets, 14.3% had become pregnant. There were no pregnancies among the 30 who received 2 insertions. All the women were found to be in good health. No long‐term side effects or complications were identified. Conclusions: The two‐insertion protocol is unmistakably superior to the single insertion. This study provides further evidence that QS is a safe contraceptive method.