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Serum levels of insulin, IGF‐1, and IGFBP‐1 in pre‐eclampsia and eclampsia
Author(s) -
Ingec M.,
Gursoy H.G.,
Yildiz L.,
Kumtepe Y.,
Kadanali S.
Publication year - 2004
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/s0020-7292(03)00342-4
Subject(s) - eclampsia , medicine , insulin like growth factor , endocrinology , insulin like growth factor binding protein , case control study , insulin , growth factor , pregnancy , receptor , biology , genetics
Objectives: To investigate whether the serum concentrations of insulin, insulin‐like growth factor‐1 (IGF‐1), and insulin‐like growth factor binding protein‐1 (IGFBP‐1) were altered in women with mild pre‐eclampsia, severe pre‐eclampsia, and eclampsia. Methods: In this prospective study, we investigated 20 mild pre‐eclamptic, 20 severe pre‐eclamptic, and 20 eclamptic patients in the third trimester. The control group consisted of 20 healthy pregnant women. Serum levels of insulin, IGF‐1, and IGFBP‐1 were measured. Results: In patients with eclampsia, serum levels of IGF‐1 were lower, and IGFBP‐1 were higher, respectively, than control and other study groups ( P <0.001) The values of IGF‐1 in mild pre‐eclampsia and severe pre‐eclampsia were lower compared with control groups (both P <0.01), but there were no differences between mild and severe pre‐eclampsia. The serum levels of IGFBP‐1 in severe pre‐eclampsia were higher compared with control groups ( P <0.01), but there was no statistical difference between mild pre‐eclampsia and other groups. Conclusions: IGF‐1 was lower, and IGFBP‐1 was higher in pre‐eclamptic and eclamptic patients than controls, these alterations were related to the severity of pre‐eclampsia.