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Endogenous urinary steroids in premenopausal women with uterine leiomyomas
Author(s) -
Jung B.H.,
Bai S.W.,
Chung B.C.
Publication year - 2004
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/s0020-7292(03)00336-9
Subject(s) - androsterone , medicine , endocrinology , metabolite , estrone , urine , urinary system , etiocholanolone , estrogen , uterine leiomyoma , hormone , uterus , steroid
Objectives: To study the effect of endogenous steroids on the presence of uterine leiomyomas. Methods: Urine samples of 27 premenopausal women with leiomyomas and 25 age‐matched healthy premenopausal women were collected. The concentration of estrogens and androgens in the urine samples of the two groups were determined using a gas chromatography mass spectrometer and the two groups were compared. To study metabolic changes in patients indirectly, the concentration ratios of precursor metabolite to product metabolite of the two groups were also compared. Results: Urinary concentrations of 17 β ‐estradiol, 5‐androstene‐3 β , 16 β , 17 β , triol, 11‐keto‐ethiocholanolone, 11 β ‐hydroxy‐androsterone, 11 β ‐hydroxy‐etiocholanolone, THS, THA, THE, α ‐cortol and β ‐cortol were significantly higher in patients than in controls. The concentration ratios of 17 β ‐estradiol/estrone and 11/ β ‐hydroxy‐ethiocholanolone/11 β ‐hydroxy‐androsterone increased in patients. Conclusions: The presence of uterine leiomyomas correlates with an increase in urinary concentrations of estrogens and androgens, and it appears to be caused by a decrease in patients’ metabolism of steroids.