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Primipaternity and duration of exposure to sperm antigens as risk factors for pre‐eclampsia
Author(s) -
Verwoerd G.R,
Hall D.R,
Grové D,
Maritz J.S,
Odendaal H.J
Publication year - 2002
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/s0020-7292(02)00130-3
Subject(s) - cohabitation , medicine , eclampsia , logistic regression , demography , risk factor , gynecology , obstetrics , pregnancy , sociology , biology , political science , law , genetics
Objective: To establish whether primipaternity and duration of unprotected sexual cohabitation is associated with an increased risk of pre‐eclampsia. Method: At a tertiary referral center, the study had a case and control group of 60 multigravid women each, as well as a case and control group of 50 primigravid women each. Information was compiled by means of a confidential questionnaire. Result: After multiple logistic regression analysis using age, smoking, hypertension in previous pregnancies, change of paternity and duration of unprotected sexual cohabitation as predictors, the regression coefficients for change of paternity and sexual cohabitation of longer than 6 months in multigravid women were −0.4 ( P =0.15) and −1.4 ( P =0.03), respectively. Conclusion: Multigravid women with a period of unprotected sexual cohabitation of longer than 6 months had a decreased risk of pre‐eclampsia. Primipaternity was not a significant risk factor for pre‐eclampsia.