Premium
Urinary protein excretion and expectant management of early onset, severe pre‐eclampsia
Author(s) -
Hall D.R.,
Odendaal H.J.,
Steyn D.W.,
Grové D.
Publication year - 2002
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/s0020-7292(02)00008-5
Subject(s) - proteinuria , medicine , eclampsia , gestation , urine , pregnancy , obstetrics , urinary system , excretion , prospective cohort study , kidney , biology , genetics
Objective: To evaluate the importance of proteinuria in the expectant management of early onset, severe pre‐eclampsia. Methods: In this prospective series of 340 women, 24‐h urine collections were performed and monitored twice weekly in a high‐care ward. Results: Seventy‐four women with at least two 24‐h urine collections were grouped into women with a proteinuria increase of ≥2 g ( n =29) and with women whose proteinuria decreased, or increased by <2 g ( n =45). Major maternal complications, prolongation of gestation, and perinatal outcomes were comparable. Fifty‐six (75%) women experienced an increase in proteinuria. When patients with heavy proteinuria ( n =83) were compared to those with moderate proteinuria ( n =257), maternal and perinatal outcomes were comparable. More days were gained before delivery in the heavy proteinuria group than in the moderate (12 vs. 9; P <0.001). Conclusion: Most patients experienced increased proteinuria. Neither the rate of increase nor the amount of proteinuria affected maternal and perinatal outcomes.