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New considerations for the pathogenesis of endometriosis
Author(s) -
Gazvani R,
Templeton A
Publication year - 2002
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/s0020-7292(01)00577-x
Subject(s) - endometriosis , pathogenesis , medicine , etiology , peritoneal cavity , pathological , angiogenesis , disease , immunology , immune system , pathology , cancer research , anatomy
Objectives: To review the available evidence regarding the immunological, epidemiological and other factors involved in the pathogenesis of endometriosis. Methods: Literature review. Results: Endometriosis remains a poorly‐understood disease of unknown etiology and pathogenesis. Conclusions: There is evidence to suggest that alterations in the immune response, whether genetically transmitted or environmentally induced, predispose women to the ectopic implantation of endometrial cells transported into the peritoneal cavity by way of retrograde menstruation. This predisposition may exist because of an impaired peritoneal clearing of endometrial cells and fragments or because of pathological angiogenesis.