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Long‐term treatment with nicardipine for severe pre‐eclampsia
Author(s) -
Seki H,
Takeda S,
Kinoshita K
Publication year - 2002
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/s0020-7292(01)00569-0
Subject(s) - medicine , nicardipine , eclampsia , term (time) , obstetrics , pregnancy , calcium , physics , biology , genetics , quantum mechanics
Objective: To evaluate the safety of long‐term nicardipine treatment in severely pre‐eclamptic women and their fetuses/newborns. Methods: We divided 50 pregnant women into three groups according to the length of their treatment: short‐term treatment of severely pre‐eclamptic women (7 days or less, n =20); medium‐term treatment also of severely pre‐eclamptic women (8–28 days, n =20); and long‐term treatment of women with severe superimposed pre‐eclampsia (29 days or more, n =10). Results: Nicardipine significantly lowered both systolic ( P <0.01) and diastolic blood pressures ( P <0.025) in all three groups. The incidence of delivery before 28 weeks of gestation was very low in all three groups. There were no maternal or fetal/neonatal adverse effects. Conclusion: Our results suggest that long‐term treatment with nicardipine for severe pre‐eclampsia is as effective and safe as a short‐ and medium‐term treatment.