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Efficacy of 7‐day treatment with metronidazole+miconazole (Neo‐Penotran®) — a triple‐active pessary for the treatment of single and mixed vaginal infections
Author(s) -
Ozyurt E.,
Toykuliyeva M.B.,
Danilyans I.L.,
Morton O.,
Baktir G.
Publication year - 2001
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/s0020-7292(01)00388-5
Subject(s) - medicine , miconazole nitrate , metronidazole , pessary , vaginitis , bacterial vaginosis , miconazole , trichomoniasis , vaginal disease , cure rate , antibiotics , surgery , vagina , gynecology , dermatology , microbiology and biotechnology , antifungal , biology
Objective: To evaluate the efficacy of Neo‐Penotran® pessaries (metronidazole 500 mg+miconazole nitrate 100 mg) in candidal, bacterial and trichomonal vaginitis and in mixed vaginal infections. Method: Ninety‐seven patients with clinical diagnosis of vaginitis entered this open, non‐comparative study. Each patient inserted one pessary twice daily for 7 days. Gynecological and microbiological assessments were carried out before, and 8–10/21–23 days after the start of treatment. Results: Vaginitis symptoms were resolved in 91% of the 74 patients evaluated, and improved in a further 7%. Microbiological cure rates were 97.3% for trichomonal, 86.6% for bacterial and 81% for candidal vaginitis. Recurrence rates were 2.7, 3.8 and 16.1%, respectively. Overall microbiological cure rate for mixed infections was 86%, with 93% for trichomonal+bacterial, and 73% for bacterial+candidal vaginitis. In two out of three cases with trichomonal+bacterial+candidal infection, the microorganisms were eradicated completely. Conclusion: Neo‐Penotran® provides immediate and effective treatment for vaginitis, irrespective of single or multiple infection, even when the diagnosis may be uncertain.