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Nucleated red blood cells as a marker in acute and chronic fetal asphyxia
Author(s) -
Saraçoglu F.,
Sahin I.,
Eser E.,
Göl K.,
Türkkani B.
Publication year - 2000
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/s0020-7292(00)00259-9
Subject(s) - medicine , umbilical cord , fetal distress , fetus , nucleated red blood cell , acidosis , fetal hypoxia , asphyxia , gastroenterology , obstetrics , pregnancy , immunology , genetics , biology
Objective: To investigate the variations of nucleated red blood cell (NRBC) counts in acute and chronic fetal hypoxia and to examine if it could be possible to establish a cutoff value for the number of NRBCs for prediction of fetal acidosis. Method: We prospectively studied 77 pregnant women. Patients were grouped as acute ( n =11) and chronic fetal distress ( n =21) and controls ( n =45). At delivery the umbilical cord was double clamped and blood samples were collected. Results: The mean NRBC counts in chronic fetal distress group was higher than acute fetal distress. NRBC counts were found to be correlated with umbilical cord pH ( r =−0.57; P <0.001). The cutoff value predicting fetal acidosis was determined as 14/100 leukocytes (sensitivity 87%, specificity 81%) by using ROC analysis. Conclusion: The duration and the severity of fetal asphyxia may be predicted by the number of NRBCs per leukocyte.