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Release of a product of growth arrest‐specific gene 6 from rat platelets
Author(s) -
Ishimoto Yoshikazu,
Nakano Toru
Publication year - 2000
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(99)01795-0
Subject(s) - gas6 , platelet , thrombin , hemostasis , secretion , microbiology and biotechnology , gene product , chemistry , gene , biochemistry , biology , phosphorylation , medicine , gene expression , immunology , receptor tyrosine kinase
A product of growth arrest‐specific gene 6 (Gas6) is known to be synthesized by growth‐arrested cells. In this study, we found that several rat tissues including platelets contain Gas6 and activation of the platelets with thrombin provoked the release of Gas6. ADP and collagen, which as well as thrombin stimulated release of ATP from platelets, also enhanced the release of Gas6, suggesting that the mechanism of its release was similar to that of ATP release. This study provides the first evidence of growth arrest‐independent secretion of Gas6 and suggests the involvement of Gas6 in vascular diseases as well as hemostasis.