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Ozone potentiates vitamin E depletion by ultraviolet radiation in the murine stratum corneum
Author(s) -
Valacchi Giuseppe,
Weber Stefan U.,
Luu Chate,
Cross Carroll E.,
Packer Lester
Publication year - 2000
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(99)01787-1
Subject(s) - stratum corneum , hairless , chemistry , oxidative stress , ultraviolet radiation , ultraviolet , vitamin , ozone , biochemistry , biology , radiochemistry , organic chemistry , materials science , genetics , optoelectronics
As the outermost layer of the skin, the stratum corneum is exposed to environmental oxidants. To investigate putative synergisms of environmental oxidative stressors in stratum corneum, hairless mice were exposed to ultraviolet radiation (UV) and ozone (O 3 ) alone and in combination. Whereas a significant depletion of α‐tocopherol was observed after individual exposure to either a 0.5 minimal erythemal dose of UV or 1 ppm O 3 for 2 h, the combination did not increase the effect of UV alone. However, a dose of 0.5 ppm O 3 ×2 h, which had no effect when used alone, significantly enhanced the UV‐induced depletion of vitamin E. We conclude that concomitant exposure to low doses of UV and O 3 at levels near those that humans can be exposed to causes additive oxidative stress in the stratum corneum.