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Aberrant overexpression of 53BP2 mRNA in lung cancer cell lines
Author(s) -
Mori Toshiyuki,
Okamoto Hiroshi,
Takahashi Naoko,
Ueda Ryuzo,
Okamoto Takashi
Publication year - 2000
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(99)01726-3
Subject(s) - messenger rna , microbiology and biotechnology , cell culture , gene , tumor suppressor gene , biology , gene expression , mutation , cancer research , cell , suppressor , carcinogenesis , genetics
The p53‐binding protein 2 (53BP2) was identified as a binding protein to a tumor suppressor p53. We examined the genetic aberrations of 53BP2 gene in various human cancer cell lines. Although no gross genomic alteration or mutation of 53BP2 gene was observed, 53BP2 mRNA levels were highly variable. There was no association between the 53BP2 mRNA level and the p53 status. When we examined sensitivities of these cell lines to DNA‐damaging agents including UV irradiation, X‐ray irradiation and cis ‐diamine‐dichloroplatinum (CDDP), we found that higher 53BP2 mRNA expression was correlated with the sensitivity to these agents.