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Glucose regulates pancreatic preprosomatostatin I expression
Author(s) -
Melroe Gregory T,
Ehrman Melissa M,
Kittilson Jeffrey D,
Sheridan Mark A
Publication year - 2000
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(99)01723-8
Subject(s) - somatostatin , pancreatic islets , in vivo , medicine , endocrinology , rainbow trout , in vitro , chemistry , carbohydrate metabolism , messenger rna , phosphorylation , metabolism , biology , insulin , islet , biochemistry , fish <actinopterygii> , gene , microbiology and biotechnology , fishery
Rainbow trout were used as a model system to evaluate the role of glucose in regulating the expression of preprosomatostatin I. Glucose increased pancreatic levels of preprosomatostatin I mRNA in vivo, in concert with elevated plasma somatostatin levels, and in vitro. Glucose‐stimulated expression of preprosomatostatin I mRNA required the uptake, phosphorylation, and subsequent metabolism of the sugar in pancreatic islets. These results suggest that glucose modulates both the production and release of somatostatin.