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Identification of a cis ‐acting element that interferes with thyroid hormone induction of the neurogranin ( NRGN ) gene
Author(s) -
Morte Beatriz,
Martı́nez de Arrieta Cruz,
Manzano Jimena,
Coloma Antonio,
Bernal Juan
Publication year - 1999
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(99)01706-8
Subject(s) - transactivation , neurogranin , thyroid hormone receptor , thyroid , gene , biology , pax8 , hormone , thyroid hormone receptor beta , microbiology and biotechnology , gene expression , signal transduction , endocrinology , genetics , transcription factor , hormone receptor , cancer , protein kinase c , breast cancer
The neuron‐specific RC3/neurogranin gene is regulated by thyroid hormone at the transcriptional level in brain and in cultured neuronal cells. Regulation in vivo displays exquisite regional selectivity which is not due to differential distribution of thyroid receptors and is most probably related to region‐specific trans ‐acting elements. We have previously identified an intronic thyroid hormone responsive element in the human RC3 gene homolog, NRGN . In a search for cis ‐acting elements that might contribute to the specificity of thyroid regulation, we have identified a novel sequence, TTCCAAAATGG, which binds to a developmentally regulated protein, and interferes with T3 transactivation.