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The transporter associated with antigen processing TAP: structure and function
Author(s) -
Lankat-Buttgereit Brigitte,
Tampé Robert
Publication year - 1999
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(99)01676-2
Subject(s) - transporter associated with antigen processing , antigen processing , endoplasmic reticulum , antigen presentation , mhc class i , microbiology and biotechnology , major histocompatibility complex , chaperone (clinical) , transport protein , cytosol , antigen , cytotoxic t cell , chemistry , intracellular , transporter , biology , biochemistry , in vitro , gene , immunology , medicine , enzyme , pathology
The transport of antigenic peptides from the cytosol to the lumen of the endoplasmic reticulum (ER) is an essential process for presentation to cytotoxic T‐lymphocytes. The transporter associated with antigen processing (TAP) is responsible for the intracellular translocation of peptides across the membrane of the ER. Efficient assembly of MHC‐peptide complex requires the formation of a macromolecular transport and chaperone complex composed of TAP, tapasin and MHC class I molecules. Therefore, structure and function of TAP is important for the understanding of the immune surveillance.