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Cell swelling activates STAT1 and STAT3 proteins in cultured rat hepatocytes
Author(s) -
Meisse Delphine,
Dusanter-Fourt Isabelle,
Husson Annie,
Lavoinne Alain
Publication year - 1999
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(99)01643-9
Subject(s) - phosphorylation , stat3 , stat4 , microbiology and biotechnology , stat5 , tyrosine phosphorylation , chemistry , tyrosine , stat1 , stat , biochemistry , biology
In this paper, we demonstrated that in cultured rat hepatocytes cell swelling induced the activation of STAT1 and STAT3 proteins without any effect on STAT4, STAT5 and STAT6 proteins. Cell swelling induced an activation of STAT proteins through an increase in the phosphorylation of the tyrosine residue also phosphorylated by interleukin‐6, but without any activation of JAK kinases. The signaling pathway by which cell swelling activated STAT1 and STAT3 is discussed.