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Photosensitive liposomes as ‘cages’ for laser‐triggered solute delivery: the effect of bilayer cholesterol on kinetics of solute release
Author(s) -
Bisby Roger H,
Mead Carole,
Morgan Christopher G
Publication year - 1999
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(99)01612-9
Subject(s) - liposome , kinetics , bilayer , biophysics , chemistry , lipid bilayer , cholesterol , laser , membrane , biochemistry , optics , biology , physics , quantum mechanics
Liposomes containing acyl chains incorporating azobenzene chromophores have been investigated as potential ‘caging’ agents for fast solute release. On photolysis, trapped marker dye can be released from gel‐phase liposomes within milliseconds. Solute release is markedly sensitive to the presence of cholesterol in the bilayer. Phospholipids bearing one saturated acyl chain and an azobenzene‐substituted chain are ineffective as sensitisers unless cholesterol is present, while doubly substituted phospholipids sensitise release in its absence. Cholesterol markedly affects the temperature profile of solute release depending on the host phospholipid chain length. Solute release is not seen for lipid hosts with unsaturated acyl chains.