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Increased leukotriene A 4 hydrolase expression in the heart of angiotensin II‐induced hypertensive rat
Author(s) -
Ishizaka Nobukazu,
Nakao Akihide,
Ohishi Nobuya,
Suzuki Masatoshi,
Aizawa Toru,
Taguchi Jun-ichi,
Nagai Ryozo,
Shimizu Takao,
Ohno Minoru
Publication year - 1999
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(99)01607-5
Subject(s) - angiotensin ii , hydrolase , downregulation and upregulation , angiotensin converting enzyme 2 , leukotriene b4 , chemistry , renin–angiotensin system , endocrinology , medicine , inflammation , enzyme , biochemistry , blood pressure , disease , covid-19 , infectious disease (medical specialty) , gene
Leukotriene A 4 (LTA 4 ) hydrolase is essential for the conversion of LTA 4 to LTB 4 , an inflammatory lipid mediator. We investigated whether LTA 4 hydrolase was regulated in the heart by angiotensin II (ang II) infusion. Continuous ang II infusion via an osmotic minipump for up to 7 days upregulated mRNA and protein levels of LTA 4 hydrolase (∼3.5‐fold of control) in the heart in a pressor‐dependent manner. Immunohistochemistry demonstrated intense LTA 4 hydrolase staining in the myofibroblast as well as migrated monocytes/macrophages. These data suggest that the cardiac LTA 4 hydrolase‐LTB 4 system plays a positive role in the promotion of cardiac inflammation in hypertension.