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AATF, a novel transcription factor that interacts with Dlk/ZIP kinase and interferes with apoptosis 1
Author(s) -
Page Grit,
Lödige Inga,
Kögel Donat,
Scheidtmann Karl Heinz
Publication year - 1999
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(99)01529-x
Subject(s) - transactivation , transcription factor , kinase , biology , leucine zipper , microbiology and biotechnology , apoptosis , serine , phosphoprotein , genetics , phosphorylation , gene
Dlk, also known as ZIP kinase, is a serine/threonine kinase that is tightly associated with nuclear structures. Under certain conditions, which require cytoplasmic localization, Dlk can induce apoptosis. In search for interaction partners that might serve as regulators or targets of this kinase we identified apoptosis antagonizing transcription factor (AATF), a nuclear phosphoprotein of 523 amino acids. The 1.8 kb mRNA seems to be ubiquitously expressed. AATF contains an extremely acidic domain and a putative leucine zipper characteristic of transcription factors. Indeed, a Gal4‐BD‐AATF fusion protein exhibited strong transactivation activity. Interestingly, AATF interfered with Dlk‐induced apoptosis.