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Two tetrodotoxin‐resistant sodium channels in human dorsal root ganglion neurons
Author(s) -
Dib-Hajj S.D.,
Tyrrell L.,
Cummins T.R.,
Black J.A.,
Wood P.M.,
Waxman S.G.
Publication year - 1999
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(99)01519-7
Subject(s) - dorsal root ganglion , sodium channel , tetrodotoxin , neuroscience , dorsum , trigeminal ganglion , nociception , chemistry , biophysics , anatomy , biology , sodium , receptor , biochemistry , sensory system , organic chemistry
Two tetrodotoxin‐resistant (TTX‐R) voltage‐gated sodium channels, SNS and NaN, are preferentially expressed in small dorsal root ganglia (DRG) and trigeminal ganglia neurons, most of which are nociceptive, of rat and mouse. We report here the sequence of NaN from human DRG, and demonstrate the presence of two TTX‐R currents in human DRG neurons. One current has physiological properties similar to those reported for SNS, while the other displays hyperpolarized voltage‐dependence and persistent kinetics; a similar TTX‐R current was recently identified in DRG neurons of sns‐null mouse. Thus SNS and NaN channels appear to produce different currents in human DRG neurons.