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Lipoprotein lipase, a key role in atherosclerosis?
Author(s) -
Mead James R.,
Cryer Anthony,
Ramji Dipak P.
Publication year - 1999
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(99)01495-7
Subject(s) - lipoprotein lipase , monoacylglycerol lipase , foam cell , adipose tissue , lipid metabolism , chylomicron , biochemistry , lipase , enzyme , chemistry , lipoprotein , biology , cholesterol , very low density lipoprotein , endocannabinoid system , receptor
Lipoprotein lipase (LPL) plays a central role in lipid metabolism and transport by catalysing the hydrolysis of triacylglycerol‐rich lipoproteins. The importance of LPL expressed by the adipose tissue and muscles in the provision of non‐esterified fatty acids and 2‐monoacylglycerol for tissue utilisation is well established. However, recent studies on LPL expressed by cells of the vascular wall, particularly macrophages, have identified additional actions of the enzyme that contribute to the promotion of foam cell formation and atherosclerosis. This review deals with the role of LPL in atherosclerosis, and its regulation by mediators that are known to be present in the lesion.