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The role of polymorphonuclear leukocytes and oxygen‐derived free radicals in experimental acute pancreatitis: mediators of local destruction and activators of inflammation
Author(s) -
Poch Bertram,
Gansauge Frank,
Rau Bettina,
Wittel Uwe,
Gansauge Susanne,
Nüssler Andreas K.,
Schoenberg Michael,
Beger Hans G.
Publication year - 1999
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(99)01470-2
Subject(s) - inflammation , acute pancreatitis , polymorphonuclear leukocyte , radical , immunology , chemistry , medicine , pancreatitis , biochemistry , in vitro
Using a retrograde infusion sodium taurocholate pancreatitis model in the rat treatment with oxygen radical scavengers or monoclonal anti‐ICAM‐1 antibody decreased tissue damage and polymorphonuclear leukocytes (PMN) infiltration. Scavengers or anti‐ICAM‐1 treatment attenuated the activating capacity of blood PMNs following zymosan stimulation. The local production of oxygen free radicals in the pancreas by systemic infusion of hypoxanthine and regional infusion of xanthine oxidase did not induce acute pancreatitis, although an increase of infiltrating PMNs was observed. Our data suggest that oxygen free radicals and infiltrating PMNs aggravate acute pancreatitis and that both are important mediators of local destruction and systemic activation of PMNs.