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Tetraspanins expressed in the embryonic chick nervous system
Author(s) -
Perron Jeanette C.,
Bixby John L.
Publication year - 1999
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(99)01429-5
Subject(s) - tetraspanin , biology , nervous system , spinal cord , microbiology and biotechnology , gdf7 , embryonic stem cell , alternative splicing , central nervous system , clone (java method) , axon guidance , messenger rna , axon , neuroscience , gene , genetics , cell
Proteins of the tetraspanin superfamily participate in the formation of plasma membrane signaling complexes; recent evidence implicates neuronal tetraspanins in axon growth and target recognition. We used a degenerate PCR screen to identify cDNAs encoding tetraspanins expressed in the embryonic spinal cord. Two cDNAs identified apparently represent chick homologues of NAG‐2 (cnag) and CD9 (chCD9). A third clone encodes a novel tetraspanin (neurospanin). All three mRNAs are widely expressed but exhibit developmentally distinct patterns of expression in the nervous system. Both neurospanin and cnag exhibit high relative expression in nervous tissue, including brain, spinal cord and dorsal root ganglia (DRG).