Premium
Molecular cloning of a novel CC chemokine, interleukin‐11 receptor α‐locus chemokine (ILC), which is located on chromosome 9p13 and a potential homologue of a CC chemokine encoded by molluscum contagiosum virus
Author(s) -
Ishikawa-Mochizuki Izumi,
Kitaura Motoji,
Baba Masataka,
Nakayama Takashi,
Izawa Dai,
Imai Toshio,
Yamada Hidekazu,
Hieshima Kunio,
Suzuki Ryuji,
Nomiyama Hisayuki,
Yoshie Osamu
Publication year - 1999
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(99)01406-4
Subject(s) - ccl21 , chemokine receptor , chemokine , xcl2 , biology , c c chemokine receptor type 6 , virology , ccl13 , ccl20 , cc chemokine receptors , ccl7 , microbiology and biotechnology , genetics , receptor
Molluscum contagiosum virus (MCV) encodes a CC chemokine MC148R which is likely to have been acquired from the host. By a homology search employing MC148R as a probe, we have identified a novel CC chemokine whose gene exists next to the IL‐11 receptor α (IL‐11Rα) gene in both humans and mice. Thus, this chemokine maps to chromosome 9p13 in humans where IL‐11Rα has been assigned. We term this novel chemokine IL‐11Rα‐locus chemokine (ILC). ILC has the highest homology to MC148R among the known human CC chemokines. Furthermore, ILC is strongly and selectively expressed in the skin where infection of MCV also takes place. Thus, ILC is likely to be the original chemokine of MC148R.