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Sphingosine‐1‐phosphate modulates growth and adhesion of ovarian cancer cells
Author(s) -
Hong Guiying,
Baudhuin Linnea M.,
Xu Yan
Publication year - 1999
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(99)01400-3
Subject(s) - sphingosine 1 phosphate , sphingosine , cell growth , ovarian cancer , microbiology and biotechnology , programmed cell death , cancer cell , cell adhesion , chemistry , cell , adhesion , calcium , biology , cancer , apoptosis , biochemistry , medicine , receptor , organic chemistry
Sphingosine‐1‐phosphate (S1P) is a bioactive lipid molecule. It stimulates the growth of some cells, but inhibits the growth of others. In this study, we describe the detection of sub‐μM to μM concentrations of S1P in the ascitic fluids of patients with ovarian cancer. In ovarian cancer cells cultured in vitro, S1P exhibited a dual effect on growth and/or survival. S1P (10 μM) induced cell death when cells were in suspension but stimulated cell growth when cells were attached. The calcium‐dependent induction of cell death by S1P is apparently associated with its inhibitory effect on cell attachment and cell adhesion. S1P (10–30 μM) also induced calcium‐dependent cell‐cell aggregation.