Premium
Phospholipin, a novel heterodimeric phospholipase A2 from Pandinus imperator scorpion venom
Author(s) -
Conde Renaud,
Zamudio Fernando Z,
Becerril Baltazar,
Possani Lourival D
Publication year - 1999
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(99)01392-7
Subject(s) - venom , pentapeptide repeat , protein subunit , complementary dna , biology , protein primary structure , peptide sequence , phospholipase a2 , gene , biochemistry , microbiology and biotechnology , peptide , enzyme
The primary structure of a phospholipase A2, with unique structural and functional characteristics, was determined. The large subunit has 108 amino acid residues, linked by a disulfide bridge to the small subunit, which contains 17 residues. Its gene was cloned from a cDNA library. The nucleotide sequence showed that the same RNA messenger encodes both subunits, separated only by a pentapeptide, that is processed during maturation.