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Cloning and characterization of Bδ, a novel regulatory subunit of protein phosphatase 2A
Author(s) -
Strack Stefan,
Chang Dennis,
Zaucha Julie A.,
Colbran Roger J.,
Wadzinski Brian E.
Publication year - 1999
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(99)01377-0
Subject(s) - protein phosphatase 2 , protein subunit , subcellular localization , phosphatase , cloning (programming) , g alpha subunit , epitope , biology , microbiology and biotechnology , gamma aminobutyric acid receptor subunit alpha 1 , biochemistry , chemistry , enzyme , gene , antibody , genetics , computer science , programming language
Variable regulatory subunits of protein phosphatase 2A (PP2A) modulate activity, substrate selectivity and subcellular targeting of the enzyme. We have cloned a novel member of the B type regulatory subunit family, Bδ, which is most highly related to Bα. Bδ shares with Bα epitopes previously used to generate subunit‐specific antibodies. Like Bα, but unlike Bβ and Bγ which are highly brain‐enriched, Bδ mRNA and protein expression in tissues is widespread. Bδ is a cytosolic subunit of PP2A with a subcellular localization different from Bα and may therefore target a pool of PP2A holoenzymes to specific substrates.