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A 22 kDa polyanion inhibits carnitine‐dependent fatty acid oxidation in rat liver mitochondria
Author(s) -
Turkaly Peter,
Kerner Janos,
Hoppel Charles
Publication year - 1999
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(99)01354-x
Subject(s) - palmitoylcarnitine , carnitine , beta oxidation , biochemistry , mitochondrion , porin , carnitine o palmitoyltransferase , chemistry , inner mitochondrial membrane , carnitine palmitoyltransferase i , hexokinase , fatty acid , enzyme , bacterial outer membrane , glycolysis , escherichia coli , gene
The transport of activated fatty acids across the mitochondrial outer membrane has not been fully addressed. A polyanion ( M n =22 kDa) inhibited the ADP‐stimulated carnitine‐dependent oxidation of both palmitoyl‐CoA and palmitate plus CoA as well as mitochondrial hexokinase binding. In contrast, the oxidation of palmitoylcarnitine plus malate, as well as glutamate oxidation, was essentially unaffected. Mitochondrial carnitine palmitoyltransferase‐1 was not inhibited by the polyanion. The data suggest an additional component in carnitine‐dependent mitochondrial fatty acid oxidation, possibly porin.