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Human apolipoprotein A‐IV reduces gastric acid secretion and diminishes ulcer formation in transgenic mice
Author(s) -
Vergnes Laurent,
Baroukh Nadine,
Léhy Thérèse,
Moizo Laurent,
Bado André,
Baralle Marco,
Baralle Francisco E,
Zakin Mario M,
Ochoa Alberto
Publication year - 1999
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(99)01332-0
Subject(s) - secretion , medicine , genetically modified mouse , transgene , apolipoprotein b , endocrinology , gastric acid , endogeny , gastric mucosa , gastrin , population , chemistry , biology , stomach , biochemistry , cholesterol , gene , environmental health
We have investigated the involvement of human apolipoprotein A‐IV (apoA‐IV) in gastric acid secretion and ulcer formation in recently generated apoA‐IV transgenic mice. Compared to control littermates, transgenic animals showed a gastric acid secretion decreased by 43–77% whereas only slight variations were observed in the different cell population densities within the gastric mucosa. In addition, no variation in gastrin levels was observed. Transgenics were protected against indomethacin‐induced ulcer formation, with lesions diminishing by 45 to 64% compared to controls. These results indicate that endogenous apoA‐IV expression can regulate gastric acid secretion and ulcer development.