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A product of growth arrest‐specific gene 6 modulates scavenger receptor expression in human vascular smooth muscle cells
Author(s) -
Murao Koji,
Imachi Hitomi,
Sayo Yoshitaka,
Hosokawa Hitoshi,
Sato Makoto,
Ishida Toshihiko,
Nakano Toru,
Kodama Tatsuhiko,
Sasaguri Yasuyuki,
Takahara Jiro
Publication year - 1999
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(99)01290-9
Subject(s) - scavenger receptor , gas6 , vascular smooth muscle , foam cell , downregulation and upregulation , microbiology and biotechnology , scavenger , receptor , biology , chemistry , medicine , endocrinology , lipoprotein , gene , biochemistry , signal transduction , smooth muscle , cholesterol , receptor tyrosine kinase , antioxidant
Although Gas6 is identified as a growth factor for vascular smooth muscle cells (VSMCs), its roles in these cells have not been clearly elucidated. To examine the role of Gas6 in atherosclerosis, we examined the effects of Gas6 on scavenger receptor family expression in VSMCs. Scavenger receptor class A, one of the scavenger receptor family members, was upregulated in VSMCs by Gas6. Furthermore, the atherogenic lipoprotein, oxidized LDL, induced Gas6 production in these cells. These results indicate that Gas6 plays an important role in foam cell formation in human VSMCs.